Curriculum vitae:
Research direction and interest:
List of published articles:
1) Zong Y#, Liu Y#, Xue C#, Li B, Li X, Wang Y, Li J, Liu G, Huang X, Cao X*, Gao C*. (2022) An engineered prime editor with enhanced editing efficiency in plants. Nature Biotechnology, doi: 10.1038/s41587-022-01254-w.
2) Li S#, Lin D#, Zhang Y#, Deng M#, Chen Y, Lv B, Li B, Lei Y, Wang Y, Zhao L, Liang Y, Liu J, Chen K, Liu Z, Xiao J*, Qiu JL*, Gao C*. (2022) Genome-edited powdery mildew resistance in wheat without growth penalties. Nature, 602(7897):455-460.
3) Luo, J., Rouse, M.N., Hua, L., Li, H., Li, B., Li, T., Zhang, W., Gao, C., Wang, Y*., Dubcovsky, J*. and Chen, S*. (2021), Identification and characterization of Sr22b, a new allele of the wheat stem rust resistance gene Sr22 effective against the Ug99 race group. Plant Biotechnology Journal. https://doi.org/10.1111/pbi.13737
4) Luo, G., Shen, L., Zhao, S., Li, R., Song, Y., Song, S., Yu, K., Yang, W., Li, X., Sun, J., Wang, Y., Gao, C., Liu, D*. and Zhang, A*. (2021), Genome-wide identification of seed storage protein gene regulators in wheat through coexpression analysis. The Plant journal. https://doi.org/10.1111/tpj.15538
5) Ma S., Wang M., Wu J., Guo W., Chen Y., Li G., Wang Y., Shi W., Xia G.,Fu D., Kang Z., and Ni F. (2021). WheatOmics: a platform combining multiple omics data to acceleratefunctional genomics studies in wheat. Molecular Plant. https://doi.org/10.1016/j.molp.2021.10.006.
6) Li T#, Hu J#, Sun Y, Li B, Zhang D, Li W, Liu J, Li D, Gao C, Zhang Y*, Wang Y*. (2021) Highly efficient heritable genome editing in wheat using an RNA virus and bypassing tissue culture. Molecular Plant, http://doi: 10.1016/j.molp.2021.07.010.
7) Lin, Q., Zhu, Z., Liu, G., Sun, C., Lin, D., Xue, C., Li, S., Zhang, D., Gao, C., Wang, Y*., J-L Qiu*. (2021). Genome editing in plants with MAD7 nuclease. Journal of Genetics and Genomics. https://doi.org/10.1016/j.jgg.2021.04.003.
8) Lin Q#, Jin S#, Zong Y#, Yu H#, Zhu Z, Liu G, Kou L, Wang Y, Qiu JL, Li J*, Gao C* (2021) High-efficiency prime editing with optimized, paired pegRNAs in plants. Nature Biotechnology, doi:10.1038/s41587-021-00868-w.
9) Luo, G., Shen, L., Song, Y., Yu, K., Ji, J., Zhang, C., Yang, W., Li, X., Sun, J., Zhan, K., Cui, D., Wang, Y., Gao, C., Liu, D. and Zhang, A. (2021) The MYB family transcription factor TuODORANT1 from Triticum urartu and homolog TaODORANT1 from Triticum aestivum inhibit seed storage protein synthesis in wheat. Plant Biotechnology Journal, https://doi.org/10.1111/pbi.13604.
10) Jin S#, Fei H#, Zhu Z#, Luo Y#, Liu J, Gao S, Zhang F, Chen YH, Wang Y*, Gao C* (2020) Rationally designed APOBEC3B cytosine base editors with improved specificity. Molecular Cell, 79, 728-740.e6.
11) Li C, Zong Y, Jin S, Zhu H, Lin D, Li S, Qiu JL, Wang Y*, Gao C* (2020) SWISS: multiplexed orthogonal genome editing in plants with a Cas9 nickase and engineered CRISPR RNA scaffolds. Genome Biology, 21, 141.
12) Lin Q#, Zong Y#, Xue C#, Wang S, Jin S, Zhu Z, Wang Y, Anzalone AV, Raguram A, Doman JL, Liu DR, Gao C* (2020) Prime genome editing in rice and wheat. Nature Biotechnology, 38:582-585.
13) Si X, Zhang H, Wang Y, Chen K, Gao C* (2020) Manipulating gene translation in plants by CRISPR-Cas9-mediated genome editing of upstream open reading frames. Nature Protocols, 15, 338-363.
14) Chen K#, Wang Y#, Zhang R, Zhang H, Gao C. (2019). CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture. Annual Review of Plant Biology. 70:667-697 (# co-first author)
15) Jin S, Zong Y, Gao Q, Zhu Z, Wang Y, Qin P, Liang C, Wang D, Qiu J, Zhang F, Gao C (2019) Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science, 364, 292-295
16) Zong Y, Song Q, Li C, Jin S, Zhang D, Wang Y, Qiu J-L, Gao C. (2018). Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A. Nature Biotechnology. 36:950
17) Li C#, Zong Y#, Wang Y#, Jin S, Zhang D, Song Q, Zhang R, Gao C. (2018). Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion. Genome Biology. 19, 59. (# co-first author).
18) Zong, Y#., Wang, Y#., Li, C., Zhang, R., Chen, K., Ran, Y., Qiu, J-L,.Wang, D., Gao, C. (2017). Precise base editing in rice, wheat and maize with a Cas9- cytidine deaminase fusion. Nature Biotechnology. 35, 438. (# co-first author).
19) Wang, Y., Zong, Y and Gao, C. (2017). Wheat genome editing by sequence-specific nucleases. Methods in Molecular Biology. P169-186. DOI 10.1007/978-1-4939-7337-8.
20) Liang Z ., Chen K., Li T., Zhang Y., Wang Y., Zhao Q ., Liu J., Zhang H., Liu C., Ran Y., Gao C. (2017). Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes. Nature Communications, 8, 14261.
21) Gil-Humanes, J., Wang, Y., Liang, Z., Shan, Q., Ozuna, C. V., Sanchez-Leon, S., Baltes, N. J., Starker, C., Barro, F., Gao, C., Voytas, D. F. (2016). High-efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9. The Plant journal, 89, 1251-1262.
22) Zhang Y, Liang Z, Zong Y, Wang Y, Liu J, Chen K, Qiu J, Gao C. (2016). Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA. Nature Communications, 7, 12617.
23) Ji, X., Zhang, H., Zhang, Y., Wang, Y and Gao, C. (2015). Establishing a CRISPR–Cas-like immune system conferring DNA virus resistance in plants. Nature Plants. 1, 15144.
24) Wang, Y#., Cheng, X#., Shan, Q., Zhang, Y., Liu, J., Gao, C and Qiu, J-L. (2014). Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew. Nature Biotechnology. 32, 947-951 (# co-first author).
25) Shan Q, Wang Y, Li J, Gao C (2014) Genome editing in rice and wheat using the CRISPR/Cas system. Nature Protocols. 9, 2395-2410.
26) Shan, Q#., Wang, Y#., Li, J#., Zhang, Y., Chen, K., Liang, Z., Zhang, K., Liu, J., Xi, J.J., Qiu, J-L and Gao, C (2013). Targeted genome modification of crop plants using a CRISPR-Cas system. Nature Biotechnology. 31, 686-688 (# co-first author).
27) Shan, Q#., Wang, Y#., Chen, K#., Liang, Z., Li, J., Zhang, Y., Zhang, K., Liu, J., Voytas, D.F., Zheng, X., Zhang,Y and Gao, C. (2013). Rapid and efficient gene modification in rice and brachypodium using TALENs. Molecular Plant. 6, 1365-1368(# co-first author).
